Publications

Original Papers

2021-2024

  1. 1,3-Butadiynyl sulfide-based compact trialkyne platform molecule for sequential assembly of three azides.
    J. Taguchi, K. Tokunaga, H. Tabuchi, T. Nishiyama, I. Kii, *T. Hosoya
    Chem. Commun. Accepted. (Doi: 10.1039/D4CC05205F)
  2. Revisiting the Synthetic Utility of 4,5-Dehydro[2.2]paracyclophane.
    J. Taguchi, Y. Omoto, K. Uto, H. Tabuchi, H. Uekusa, T. Niwa, *T. Hosoya
    Adv. Synth. Catal. Accepted. (Doi: 10.1002/adsc.202400986)

  3. Chemical inhibition of phosphatidylcholine biogenesis reveals its role in mitochondrial division.
    H. Shiino, S. Tashiro, M. Hashimoto, Y. Sakata, T. Hosoya, T. Endo, H. Kojima, *Y. Tamura
    iScience 27 (3), 109189 (2024).
  4. Clickable bisreactive small gold nanoclusters for preparing multifunctionalized nanomaterials: application to photouncaging of an anticancer molecule.
    *K. Watanabe, Q. Mao, Z. Zhang, M. Hata, M. Kodera, H. Kitagishi, T. Niwa, *T. Hosoya
    Chem. Sci. 15 (4), 1402–1408 (2024).
  5. Clickable bisreactive small gold nanoclusters for preparing multifunctionalized nanomaterials: application to photouncaging of an anticancer molecule.
    *K. Watanabe, Q. Mao, Z. Zhang, M. Hata, M. Kodera, H. Kitagishi, T. Niwa, *T. Hosoya
    Chem. Sci. 15 (4), 1402–1408 (2024).
  6. Palladium-Catalyzed ipso-Borylation of Aryl Halides Promoted by Lewis Acid-Mediated Electrophilic Activation of Aryl(halo)palladium(II) Complex.
    *T. Niwa, T. Takimoto, Y. Sakata, *T. Hosoya
    Org. Lett. 25 (45), 8173–8177 (2023).
  7. Synthesis of Multisubstituted Aromatics via 3-Triazenylarynes.
    J. Taguchi, T. Okuyama, S. Tomita, T. Niwa, *T. Hosoya
    Org. Lett., 25 (xx), xxxx–xxxx (2023).
  8. 11C-Cyanation of Aryl Fluorides via Nickel and Lithium Chloride-Mediated C–F Bond Activation.
    *Z. Zhang, K. Watanabe, T. Niwa, *T. Hosoya
    Angew. Chem., Int. Ed., 62 (22), e202302956 (2023); Angew. Chem., 135 (22), e202302956 (2023).
  9. Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study.
    M. Dubol, M. Jonasson, J. Immenschuh, K. Takahashi, T. Niwa, T. Hosoya, S. Roslin, J. Wikström, G. Antoni, Y. Watanabe, M. Lubberink, A. Biegon, I. Sundström-Poromaa, *E. Comasco
    Compr. Psychiat., 123, 152381 (2023).
  10. Migrative Thioamination of Aryne Intermediates Generated from o-Iodoaryl Triflates.
    S. Tabata, M. Minoshima, A. Kobayashi, T. Matsuzawa, T. Hosoya, *S. Yoshida
    Synlett., 34 (11), 1259–1264 (2023).
  11. Synthesis of 11C-Radiolabeled Eribulin as a Companion Diagnostics PET Tracer for Brain Glioblastoma.
    T. Niwa, T. Tahara, C. E. Chase, F. G. Fang, T. Nakaoka, S. Irie, E. Hayashinaka, Y. Wada, H. Mukai, K. Masutomi, Y. Watanabe, Y. Cui, *T. Hosoya
    Bull. Chem. Soc. Jpn., 96 (3), 283–290 (2023).
    Selected as front cover, BCSJ Award Article
  12. Synthesis of benzo[b]furans from alkynyl sulfoxides and phenols by the interrupted Pummerer reaction.
    A. Kobayashi, T. Matsuzawa, T. Hosoya, *S. Yoshida
    RSC Adv., 13 (2), 839–843 (2023).
  13. Synthesis of Functionalized Dibenzoazacyclooctynes by a Decomplexation Method for Dibenzo-Fused Cyclooctyne–Cobalt Complexes.
    *Y. Sakata, R. Nabekura, Y. Hazama, M. Hanya, T. Nishiyama, I. Kii, *T. Hosoya
    Org. Lett., 25 (7), 1051–1055 (2023).
    [プレスリリース]
  14. Substitution of α-Azido Sulfones with Thiolates to Form α-Azido Sulfides.
    A. Katayama, Y. Jin, Y. Nishiyama, T. Hosoya, *S. Yokoshima
    Org. Lett., 24 (40), 7361–7365 (2022).
  15. Reverse mutants of the catalytic 19 kDa mutant protein (nanoKAZ/nanoLuc) from Oplophorus luciferase with coelenterazine as preferred substrate.
    *S. Inouye, J. Sato, Y. Sahara-Miura, Y. Tomabechi, Y. Sumida, S. Sekine, M. Shirouzu, T. Hosoya
    PLoS ONE, 17 (9), e0272992 (2022).
  16. Red light-induced conjugation of amines through amide bond formation triggered via photooxidation of 3-acylindolizines.
    *K. Watanabe, A. Kuratsu, D. Hashizume, T. Niwa, T. Hosoya
    Commun. Chem., 5, 91 (2022).
  17. Azido-type-selective triazole formation by iridium-catalyzed cycloaddition with thioalkynes.
    K. Sugiyama, Y. Sakata, T. Niwa, S. Yoshida, *T. Hosoya
    Chem. Commun., 58 (42), 6235–6238 (2022).
  18. Synthesis of Multisubstituted Benzenes from Phenols via Multisubstituted Benzynes.
    A. Nagai, A. Kobayashi, Y. Sakata, Y. Minami, K. Uchida, T. Hosoya, *S. Yoshida
    Synthesis, 54, (22), 5017–5025 (2022).
  19. Computational Study for Amino Acid Production from Carboxylic Acid via 14C β-decay.
    *T. Fukuchi, T. Niwa, T. Hosoya, Y. Watanabe
    J. Phys. Soc. Jpn., 91 (6), 064301 (2022).
  20. Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY.
    N. Kimura, K. Saito, T. Niwa, M. Yamanaka, S. Igaue, J. Ohkanda, T. Hosoya, *I. Kii
    Protein Expres. Purif. 195–196, 106089 (2022).
  21. Modular synthesis of triazoles from 2-azidoacrylamides having a nucleophilic amino group.
    H. Takemura, G. Orimoto, A. Kobayashi, T. Hosoya, *S. Yoshida
    Org. Biomol. Chem. 20 (30), 6007–6011 (2022).
  22. Hydride reduction of o-(fluorosilyl)benzodifluorides for subsequent C–F transformations.
    R. Idogawa, A. Kobayashi, Y. Kim, K. Shimomori, T. Hosoya, *S. Yoshida
    Chem. Commun. 58 (21), 3521–3524 (2022).
  23. Clinical evaluation of [18F]pitavastatin for quantitative analysis of hepatobiliary transporter activity.
    T. Nakaoka, K. Kaneko, S. Irie, A. Mawatari, A. Igesaka, Y. Uetake, H. Ochiai, T. Niwa, E. Yamano, Y. Wada, M. Tanaka, K. Kotani, H. Kawahata, J. Kawabe, Y. Miki, H. Doi, T. Hosoya, K. Maeda, H. Kusuhara, Y. Sugiyama, *Y. Watanabe
    Drug Metab. Pharmacok. 44, 100449 (2022).
  24. Formation of Coelenteramine from 2-peroxycoelenterazine in the Ca2+-binding Photoprotein Aequorin.
    *S. Inouye, M. Nakamura, T. Hosoya
    Photochem. Photobiol. 98 (5), 1068–1076 (2022).
  25. Enzymatic conversion of dehydrocoelenterazine to coelenterazine using FMN-bound flavin reductase of NAD(P)H:FMN oxidoreductase.
    *S. Inouye, M. Nakamura, T. Hosoya
    Biochem. Biophys. Res. Commun. 587, 24–28 (2022).
  26. Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A.
    Y. Miyazaki, M. Kikuchi, K. Umezawa, A. Descamps, D. Nakamura, G. Furuie, T. Sumida, K. Saito, N. Kimura, T.Niwa, Y. Sumida, T. Umehara, T. Hosoya, *I. Kii
    Eur. J. Med. Chem. 227, 113948 (2022).
  27. 3-Azidoarynes: Generation and Regioselective Reactions.
    J. Taguchi, K. Kimura, K. Igawa, K. Tomooka, *T. Hosoya
    Chem. Lett. 51 (2), 94–98 (2022).
  28. PET imaging of brain aromatase in humans and rhesus monkeys by 11C-labeled cetrozole analogs.
    K. Takahashi, *T. Hosoya, K. Onoe, T. Mori, S. Tazawa, A. Mawatari, Y. Wada, Y.Watanabe, H. Doi, *Y. Watanabe
    Sci. Rep., 11, 23623 (2021).
  29. Lewis acid-mediated Suzuki–Miyaura cross-coupling reaction.
    *T. Niwa, *Y. Uetake, M. Isoda, T. Takimoto, M. Nakaoka, D. Hashizume, H. Sakurai, T. Hosoya
    Nat. Catal., 4 (12), 1080–1088 (2021).
    　
  30. Synthesis of Azidoanilines by the Buchwald−Hartwig Amination.
    Y. Sakata, S. Yoshida, *T. Hosoya
    J. Org. Chem., 86 (21), 15674–15688 (2021).
  31. Direct 3-Acylation of Indolizines by Carboxylic Acids for the Practical Synthesis of Red Light-Releasable Caged Carboxylic Acids.
    *K. Watanabe, N. Terao, T. Niwa, *T. Hosoya
    J. Org. Chem., 86 (17), 11822–11834 (2021).
  32. Thioxanthone Synthesis from Benzoic Acid Esters through Directed ortho-Lithiation.
    A. Kobayashi, T. Matsuzawa, T. Hosoya, *S. Yoshida
    Chem. Lett., 50 (9), 1624–1627 (2021).
  33. Nucleophilic transformations of azido-containing carbonyl compounds via protection of azido group.
    T. Aimi, T. Meguro, A. Kobayashi, *T. Hosoya, *S. Yoshida
    Chem. Commun., 57 (49), 6062–6065 (2021).
  34. Chiral deaza-coelenterazine analogs for probing a substrate-binding site in the Ca2+-binding
    photoprotein aequorin.
    *S. Inouye, Y. Sumida, Y. Tomabechi, J. Taguchi, M. Shirouzu, *T Hosoya
    PLoS One, 16 (6), e0251743 (2021).
  35. Facile Synthetic Methods for Diverse N-Arylphenylalanine Derivatives via Transformations of Aryne Intermediates and Cross-Coupling Reactions.
    T. Kobayashi, T. Hosoya, *S. Yoshida
    Bull. Chem. Soc. Jpn., 94 (7), 1823–1832 (2021).
  36. Palladium-Catalyzed Sulfinylation of Aryl- and Alkenylborons with Sulfinate Esters.
    M. Suzuki, K. Kanemoto, Y. Nakamura, T. Hosoya, *S. Yoshida
    Org. Lett., 23 (6), 3893–3797 (2021).
  37. Transition-Metal-Free Synthesis of N-Arylphenothiazines through an N– and S-Arylation Sequence.
    T. Matsuzawa, T. Hosoya, *S. Yoshida
    Org. Lett., 23 (6), 2347–2352 (2021).
  38. Acylalkylation of Arynes Generated from o-Iodoaryl Triflates with Hydrosilanes and Cesium Fluoride.
    M. Minoshima, K. Uchida, Y. Nakamura, T. Hosoya, *S. Yoshida
    Org. Lett., 23 (5), 1868–1873 (2021).
  39. Diverse diaryl sulfide synthesis through consecutive aryne reactions.
    H. Nakajima, Y. Hazama, Y. Sakata, K. Uchida, T. Hosoya, *S. Yoshida
    Chem. Commun., 57 (21), 2621–2624 (2021).
  40. Convergent Synthesis of Fluoroalkenes Using a Dual-Reactive Unit.
    M. Isoda, Y. Uetake, T. Takimoto, J. Tsuda, *T. Hosoya, *T. Niwa
    J. Org. Chem., 86 (2), 1622–1632 (2021).
  41. Assembly of four modules onto a tetraazide platform by consecutive 1,2,3-triazole formations.
    *S. Yoshida, Y. Sakata, Y. Misawa, T. Morita, T. Kuribara, H. Ito, Y. Koike, I. Kii, *T. Hosoya
    Chem. Commun., 57 (7), 899–902 (2021).
  42. S1PR3–G12-biased agonist ALESIA targets cancermetabolism and promotes glucose starvation.
    *M. Toyomoto, A. Inoue, K. Iida, M.Denawa, I. Kii, F. M. N. Kadji, T. Kishi, D. Im, T. Shimamura, H. Onogi, S. Yoshida, S. Iwata, J. Aoki, T. Hosoya, *M. Hagiwara
    Cell Chem. Biol., 28 (8), 1132–1144 (2021).
  43. Facile Synthesis of Tetraarylpyrazines by Sequential Cross-coupling Approach.
    Y. Nishiyama, K. Akiyama, Y. Sakata, T. Hosoya, *S. Yoshida
    Chem. Lett., 50 (1), 180–183 (2021).

2016-2020

  1. 2-Azidoacrylamides as compact platforms for efficient modular synthesis.
    H. Takemura, S. Goto, T. Hosoya, *S. Yoshida
    Chem. Commun., 56 (99), 15541–15544 (2020).
  2. Single C–F Transformations of o-Hydrosilyl Benzotrifluorides with Trityl Compounds as All-in-One Reagents.
    R. Idogawa, Y. Kim, K. Shimomori, T. Hosoya, *S. Yoshida
    Org. Lett., 22 (23), 9292–9297 (2020).
  3. Triazole formation of phosphinyl alkynes with azides through transient protection of phosphine by copper.
    N. Terashima, Y. Sakata, T. Meguro, T. Hosoya, *S. Yoshida
    Chem. Commun., 56 (90), 14003–14006 (2020).
  4. Synthesis of Functionalized Benzopyran/Coumarin-Derived Aryne Precursors and Their Applications.
    Y. Nakamura, Y. Sakata, T. Hosoya, *S. Yoshida
    Org. Lett., 22 (21), 8505–8510 (2020).
  5. Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation.
    *A. Nakano-Kobayashi, A. Fukumoto, A. Morizane, D. T. Nguyen, T. M. Le, K. Hashida, T. Hosoya, R. Takahashi, J. Takahashi, O. Hori, *M. Hagiwara
    Sci. Adv., 6 (46), eabc1428 (2020).
  6. One-step synthesis of benzo[b]thiophenes by aryne reaction with alkynyl sulfides.
    T. Matsuzawa, T. Hosoya, *S. Yoshida
    Chem. Sci., 11 (35), 9691–9696 (2020).
    日刊工業新聞 “東京医科歯科大、ベンゾチオフェン環をワンステップ合成”
  7. (Hexafluoroacetylacetonato)copper(I)–cycloalkyne complexes as protected cycloalkynes.
    N. Makio, Y. Sakata, T. Kuribara, K. Adachi, Y. Hatakeyama, T. Meguro, K. Igawa, K, Tomooka, T. Hosoya, *S. Yoshida
    Chem. Commun., 56 (77), 11449–11452 (2020).
  8. Boracene-Based Alkylborate Enabling Ni/Ir Hybrid Catalysis.
    Y. Sato, Y. Miyamoto, *Y. Sumida, T. Hosoya, *H. Ohmiya
    Org. Biomol. Chem., 18 (34), 6598–6601 (2020).
  9. Synthesis of Dibenzofurans by Cu-Catalyzed Deborylative Ring Contraction of Dibenzoxaborins
    *Y. Sumida, R. Harada, T. Sumida, K. Johmoto, H. Uekusa, *T. Hosoya
    Org. Lett., 22 (16), 6687–6691 (2020).
  10. Identification of a novel oxidation product from yellow fluorophore in the complex of apoPholasin and dehydrocoelenterazine.
    *S. Inouye, M. Nakamura, J. Taguchi, T. Hosoya
    Bioorg. Med. Chem. Lett., 30 (19), 127435 (2020).
  11. Quantification of aromatase binding in the female human brain using [11C]cetrozole PET.
    M. Jonasson, P. Nordeman, J. Eriksson, H. Wilking, J. Wikström, K. Takahashi, T. Niwa, T. Hosoya, Y. Watanabe, G. Antoni, I. S. Poromaa, *M. Lubberink, *E. Comasco
    J. Neurosci. Res., 98 (11), 2208–2218 (2020).
  12. Selective strain-promoted azide–alkyne cycloadditions through transient protection of bicyclo[6.1.0]nonynes with silver or gold.
    K. Adachi, T. Meguro, Y. Sakata, K. Igawa, K, Tomooka, T. Hosoya, *S. Yoshida
    Chem. Commun., 56 (68), 9823–9826 (2020).
  13. Indolizines Enabling Rapid Uncaging of Alcohols and Carboxylic Acids by Red Light-Induced Photooxidation.
    *K. Watanabe, N. Terao, I. Kii, R. Nakagawa, T. Niwa, *T. Hosoya
    Org. Lett., 22 (14), 5434–5438 (2020).
  14. Synthesis of multisubstituted cycloalkenes through carbomagnesiation of strained cycloalkynes
    Y. Tamura, Y. Minami, Y. Nishiyama, Y. Sakata, F. Karaki, T. Hosoya, *S. Yoshida
    Chem. Commun., 56 (52), 7147–7150 (2020).
  15. Generation of Alkyl Radical through Direct Excitation of Boracene-based Alkylborate.}
    Y. Sato, K. Nakamura, *Y. Sumida, D. Hashizume, *T. Hosoya, *H. Ohmiya
    J. Am. Chem. Soc., 142 (22), 9938–9943 (2020).
    [Press release(金沢大・理研・医科歯科大共同)]
  16. One-pot Synthesis of Allyl Sulfides from Sulfinate Esters and Allylsilanes through Reduction of Alkoxysulfonium Intermediates
    A. Kobayashi, T. Matsuzawa, T. Hosoya, *S. Yoshida
    Chem. Lett., 49 (7), 813–816 (2020).
  17. Aryne Reaction and Cross-Coupling Approach for the Synthesis of Diverse N-Arylphenylalanine Derivatives
    T. Kobayashi, T. Hosoya, *S. Yoshida
    Chem. Lett., 49 (7), 809–812 (2020).
  18. Synthesis of Diverse Aromatic Ketones through C–F Cleavage of Trifluoromethyl Group
    M. Ikeda, T. Matsuzawa, T. Morita, T. Hosoya, *S, Yoshida
    Chem. Eur. J., 26 (54), 12333-12337 (2020).
  19. Synthesis of benzyl sulfides via substitution reaction at the sulfur of phosphinic acid thioesters.
    Y. Nishiyama, T. Hosoya, *S. Yoshida
    Chem. Commun., 56 (43), 5771–5774 (2020).
  20. Practical synthesis of [18F]pitavastatin and evaluation of hepatobiliary transport activity in rats by positron emission tomography.
    T. Nakaoka, Y. Uetake, K. Kaneko, T. Niwa, H. Ochiai, S. Irie, Y. Suezaki, N. Otsuka, E. Hayashinaka, Y. Wada, Y. Cui, K. Maeda, H. Kusuhara, Y. Sugiyama, T. Hosoya, *Y. Watanabe
    Mol. Pharmaceutics, 17 (6), 1884–1898 (2020).
  21. Sulfoxide synthesis from sulfinate esters under Pummerer-like conditions.
    A. Kobayashi, T. Matsuzawa, T. Hosoya, *S. Yoshida
    Chem. Commun., 56 (40), 5429–5432 (2020).
  22. Synthesis of Thioxanthones through Formal C–H Thiolation of Benzoic Acid Esters and Acid-mediated Direct Cyclization.
    K. Mutsuura, Y. Sakata, K. Uchida, T. Hosoya, *S. Yoshida
    Chem. Lett., 49 (7), 753–756 (2020).
  23. Facile assembly of three cycloalkyne-modules onto a platform compound bearing thiophene S,S-dioxide moiety and two azido groups.
    T. Meguro, Y. Sakata, T. Morita, T. Hosoya, *S. Yoshida
    Chem. Commun., 56 (34), 4720–4723 (2020).
  24. Functionalization of a Single C–F Bond of Trifluoromethylarenes Assisted by an ortho-Silyl Group Using a Trityl‐Based All-in-One Reagent with Ytterbium Triflate Catalyst
    Y. Kim, K. Kanemoto, K. Shimomori, T. Hosoya, S. Yoshida*
    Chem. Eur. J., 26 (28), 6136–6140 (2020).
  25. A novel yellow fluorescent protein of recombinant apoPholasin with dehydrocoelenterazine
    *S. Inouye, Y. Miura-Sahara, R. Iimori, Y. Sakata, Y. Hazama, S. Yoshida, M. Nakamura, T. Hosoya
    Biochem. Biophys. Res. Commun., 526 (2), 404–409 (2020).
  26. Synthesis of Phenoxathiins and Phenothiazines by Aryne Reactions with Thiosulfonates.
    K. Kanemoto, Y. Sakata, T. Hosoya, *S. Yoshida
    Chem. Lett., 49 (5), 593–596 (2020).
  27. Expression, purification, and characterization of recombinant apoPholasin.
    *S. Inouye, Y. Sahara-Miura, M. Nakamura, T. Hosoya
    Protein Expr. Purif., 171, 105615 (2020).
  28. Consecutive Aryne Generation Strategy for the Synthesis of 1,3-Diarylpyrazoles.
    T. Kobayashi, T. Hosoya, *S. Yoshida
    J. Org. Chem., 85 (6), 4448–4462 (2020).
  29. HaloTag-based conjugation of proteins to barcoding-oligonucleotides.
    *J. Yazaki, Y. Kawashima, T. Ogawa, A. Kobayashi, M. Okoshi, T. Watanabe, S. Yoshida, I. Kii, S. Egami, M. Amagai, T. Hosoya, K. Shiroguchi, O. Ohara,
    Nucleic Acids Res., 48 (2), e8 (2020).
    [理研 プレスリリース]
  30. Cell-based high-throughput screening identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity.
    K. Kitakaze, S. Taniuchi, E. Kawano, Y. Hamada, M. Miyake, T. Kuribara, S. Yoshida, M. Oyadomari, H. Kojima, H. Kosako, T. Hosoya, *S. Oyadomari
    eLife, 8, e43302 (2019).
  31. Synthesis of Diverse γ-Aryl-β-ketoesters via Aryne Intermediates Generated by C–C Bond Cleavage.
    K. Uchida, Y. Minami, *S. Yoshida, *T. Hosoya
    Org. Lett., 21 (22), 9019–9023 (2019).
    [TMDU プレスリリース]
  32. Facile Synthesis of Diverse 2,6-Disubstituted Arylsilanes via Silylamination and Silylsulfanylation of Aryne Intermediates Generated from o-Iodoaryl Triflates.
    Y. Nakamura, S. Ozawa, *S. Yoshida, *T. Hosoya
    Chem. Lett., 48 (11), 1296–1299 (2019).
  33. 3-Thioaryne Intermediates for the Synthesis of Diverse Thioarenes.
    Y. Nakamura, Y. Miyata, K. Uchida, *S. Yoshida, *T. Hosoya
    Org. Lett., 21 (13), 5252–5258 (2019).
    [TMDU プレスリリース]
  34. Synthesis of (2,2-Diborylvinyl)arenes by Rhodium-Catalyzed Desulfanylative gem-Diborylation of 2-Arylvinyl Sulfides.
    Y. Uetake, M. Isoda, *T. Niwa, *T. Hosoya
    Org. Lett., 21 (13), 4933–4938 (2019).
  35. Effect of Resonance on the Clickability of Alkenyl Azides in the Strain-promoted Cycloaddition with Dibenzo-fused Cyclooctynes.
    *S. Yoshida, S. Goto, Y. Nishiyama, Y. Hazama, M. Kondo, T. Matsushita, *T. Hosoya
    Chem. Lett., 48 (9) 1038–1041 (2019).
  36. Synthesis of Alkynyl Sulfides by Copper-Catalyzed Thiolation of Terminal Alkynes Using Thiosulfonates.
    K. Kanemoto, *S. Yoshida, *T. Hosoya
    Org. Lett., 21 (9), 3172–3177 (2019).
    [TMDU プレスリリース]
  37. Facile Synthesis of Diverse o-Iodoaryl Triflates from o-Silylaryl Triflates by Aluminum-mediated Desilyliodination.
    *S. Yoshida, Y. Hazama, K. Kanemoto, Y. Nakamura, *T. Hosoya
    Chem. Lett., 48 (7), 742–745 (2019).
  38. Modular Synthesis of Unsymmetrical Doubly-ring-fused Benzene Derivatives Based on a Sequential Ring Construction Strategy Using Oxadiazinones as a Platform Molecule.
    T. Meguro, S. Chen, K Kanemoto, *S Yoshida, *T. Hosoya
    Chem. Lett., 48 (6), 582–585 (2019).
  39. A facile preparation of functional cycloalkynes via an azide-to-cycloalkyne switching approach.
    *S. Yoshida, T. Kuribara, H. Ito, T. Meguro, Y. Nishiyama, F. Karaki, Y. Hatakeyama, Y. Koike, I. Kii, *T. Hosoya
    Chem. Commun., 55 (24), 3556–3559 (2019).
    [TMDU プレスリリース]
  40. Divergent Synthesis of Photoaffinity Probe Candidates by Click Reactions of Azido-Substituted
    Aryltrifluoromethyldiazirines.
    K. Watanabe, J. Tsuda, H. Ochiai, T. Niwa, and *T. Hosoya
    Heterocycles, 99 (2), 1366-1387 (2019)
  41. Synthesis of Diverse 3-Azido-5-(azidomethyl)benzene Derivatives via Formal C–H Azidation and Functional Group-Selective Transformations.
    Y. Nishiyama, Y. Misawa, Y. Hazama, K. Oya, *S. Yoshida, and *T. Hosoya
    Heterocycles, 99 (2), 1053-1072 (2019)
  42. Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface.
    Y. Toyoda, K. Morimoto, R. Suno, S. Horita, K. Yamashita, K. Hirata, Y. Sekiguchi, S. Yasuda, M. Shiroishi, T. Shimizu, Y. Urushibata, Y. Kajiwara, T. Inazumi, Y. Hotta, H. Asada, T. Nakane, Y. Shiimura, T. Nakagita, K. Tsuge, S. Yoshida, T. Kuribara, T. Hosoya, Y. Sugimoto, N. Nomura, M. Sato, T. Hirokawa, K. Masahiro, T. Murata, K. Takayama, M. Yamamoto, *S. Narumiya, *S. Iwata, and *T. Kobayashi
    Nat. Chem. Biol., 15, 18-26 (2019).
  43. Association between aromatase in human brains and personality traits.
    K. Takahashi, T. Hosoya, K. Onoe, T. Takashima, M. Tanaka, A. Ishii, Y. Nakatomi, S. Tazawa, K. Takahashi, H. Doi, Y. Wada, and *Y. Watanabe
    Sci. Rep., 8, 16841; doi: 10.1038/s41598-018-35065-4 (2018)
  44. Further enhancement of the clickability of doubly sterically-hindered aryl azides by para-amino substitution.
    S. Yoshida, J. Tanaka, Y. Nishiyama, Y. Hazama, T. Matsushita, and *T. Hosoya
    Chem. Commun., 54, 13499–13502 (2018).
    [Open Access]  Selected as inside back cover.
    　
  45. Palladium(II)-mediated rapid 11C-cyanation of (hetero)arylborons
    *Z. Zhang, T. Niwa, Y. Watanabe, and *T. Hosoya
    Org. Biomol. Chem., 16, 7711–7716 (2018).
  46. Hydrosilyl Group-directed Iridium-catalyzed peri-Selective C–H Borylation of Ring-fused (Hetero)Arene.
    *Y. Sumida, R. Harada, T. Sumida, D. Hashizume, and *T. Hosoya
    Chem. Lett., 47, 1251–1254 (2018).
    [Open Access]  Selected as Editor’s Choice and front cover.
  47. Generation of Arynes by Selective Cleavage of a Carbon–Phosphorus Bond of o-(Diarylphosphinyl)aryl Triflates Usinga Grignard Reagent
    Y. Nishiyama, S. Kamada, *S. Yoshida, and *T. Hosoya
    Chem. Lett., 47, 1216–1219 (2018).
    [Open Access]
  48. Transient Protection of Organic Azides from Click Reactions with Alkynes by Phosphazide Formation.
    T. Meguro, *S. Yoshida, K. Igawa, K. Tomooka, and *T. Hosoya
    Org. Lett., 20, 4126–4130 (2018).
    [TMDU プレスリリース]
    日経産業新聞（2018年6月26日）
  49. Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors
    *S. Yoshida, T. Kuribara, T. Morita, T. Matsuzawa, K. Morimoto, T. Kobayashi, and *T. Hosoya
    RCS Adv., 8, 21754–21758 (2018).
    [Open Access] 
  50. Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells.
    T. Meguro, N. Terashima, H. Ito, Y. Koike, I. Kii, *S. Yoshida, and *T. Hosoya
    Chem. Commun., 54, 7904–7907 (2018).
    [TMDU プレスリリース]
    [Open Access]  Selected as back cover.
    　
  51. Slow luminescence kinetics of semi-synthetic aequorin: expression, purification and structure determination of cf3-aequorin.
    *S. Inouye, Y. Tomabechi, T. Hosoya, S. Sekine, and M. Shirouzu
    J. Biochem., 164, 247–255 (2018).
    Selected as front cover.
  52. CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia.
    M. Ajiro, H. Sakai, H. Onogi, M. Yamamoto, E. Sumi, T. Sawada, T. Nomura, K. Kabashima, T. Hosoya, and *M. Hagiwara
    Clin. Cancer Res., 24, 4518–4528 (2018).
    [京大 プレスリリース]
  53. Synthesis of Diverse Phenothiazines by Direct Thioamination of Arynes with S-(o-Bromoaryl)-S-methylsulfilimines and Subsequent Intramolecular Buchwald–Hartwig Amination.
    T. Matsuzawa, K. Uchida, *S. Yoshida, and *T. Hosoya
    Chem. Lett., 47, 825–828 (2018).
  54. Quantification of receptor activation by oxytocin and vasopressin in endocytosis-coupled bioluminescence reduction assayusing nanoKAZ.
    *I. Kii, S. Hirahara-Owada, M. Yamaguchi, T. Niwa, Y. Koike, R. Sonamoto, H. Ito, K. Takahashi, C. Yokoyama, T. Hayashi, T. Hosoya, and Y. Watanabe
    Anal. Biochem., 549, 174–183 (2018).
  55. Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions.
    S. Yoshida, K. Kanno, I. Kii, Y. Misawa, M. Hagiwara, and *T. Hosoya,
    Chem. Commun., 54, 3705–3708 (2018).
    [TMDU プレスリリース]
    [Open Access]  Selected as inside back cover.
  56. Modified Conditions for Copper-Catalyzed ipso-Thiolation of Arylboronic Acid Esters with Thiosulfonates.
    K. Kanemoto, *S. Yoshida, and *T. Hosoya,
    Chem. Lett., 47, 85–88 (2018).
  57. Synthesis of Diverse o-Arylthio-Substituted Diaryl Ethers by Direct Oxythiolation of Arynes with Diaryl Sulfoxides InvolvingMigratory O-Arylation.
    T. Matsuzawa, K. Uchida, *S. Yoshida, and *T. Hosoya,
    Org. Lett, 19, 5521–5524 (2017).
    [TMDU プレスリリース]
    Most read article of Org. Lett. in Oct.–Nov. 2017;  日経産業新聞（2017年10月13日）
  58. A study on an unusual SN2 mechanism in the methylation of benzyne through nickel-complexation.
    *M. Hatakeyama, Y. Sakamoto, K. Ogata, Y. Sumida, T. Sumida, T. Hosoya, and *S. Nakamura,
    Phys. Chem. Chem. Phys., 19, 26926-26933 (2017).
  59. Comparison of pharmacokinetics of newly discovered aromatase inhibitors by a cassette microdosing approach in healthy Japanese subjects.
    H. Kusuhara, T. Takashima, H. Fujii, T. Takashima, M. Tanaka, A. Ishii, S. Tazawa, K. Takahashi, K. Takahashi, H. Tokai, T. Yano, M. Kataoka, A. Inano, S. Yoshida, T. Hosoya, Y. Sugiyama, S. Yamashita, T Hojo, and *Y. Watanabe,
    Drug Metab. Pharmacok., 32, 293–300 (2017).
  60. Construction of Condensed Polycyclic Aromatic Frameworks through Intramolecular Cycloaddition Reactions Involving Arynes Bearing an Internal Alkyne Moiety.
    *S. Yoshida, K. Shimizu, K. Uchida, Y. Hazama, K. Igawa, K. Tomooka, and *T. Hosoya,
    Chem. Eur. J., 23, 15332–15335 (2017).
  61. Copper-Catalyzed Regioselective Monodefluoroborylation of Polyfluoroalkenes en Route to Diverse Fluoroalkenes.
    †H. Sakaguchi, †Y. Uetake, M. Ohashi, *T. Niwa, *S. Ogoshi, and *T. Hosoya
    J. Am. Chem. Soc., 139, 12855–12862 (2017)
  62. Rhodium-catalyzed odorless synthesis of diaryl sulfides from borylarenes and S-aryl thiosulfonates.
    K. Kanemoto, Y. Sugimura, S. Shimizu, *S. Yoshida, and *T. Hosoya
    Chem. Commun., 53, 10640–10643 (2017).
    [Open Access]  Selected as inside back cover.
    　
  63. Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice.
    A. Nakano-Kobayashi, T. Awaya, I. Kii, Y. Sumida, Y. Okuno, S. Yoshida, T. Sumida, H. Inoue, T. Hosoya, and *M. Hagiwara
    Proc. Natl. Acad. Sci. USA, 114, 10268 (2017). 
    [京大 プレスリリース]
  64. Synthesis of Unsymmetrical Tertiary Phosphine Oxides via Sequential Substitution Reaction of Phosphonic Acid Dithioesters with Grignard Reagents
    Y. Nishiyama, Y. Hazama, *S. Yoshida, and *T. Hosoya,
    Org. Lett., 19, 3899–3902 (2017). 
    [TMDU プレスリリース]
  65. Nickel-Catalyzed Reductive Cross-Coupling of Aryl Triflates and Nonaflates with Alkyl Iodides.
    *Y. Sumida, T. Sumida, and *T. Hosoya,
    Synthesis, 49, 3590–3601 (2017).
  66. Three-Dimensional Localization of an Individual Fluorescent Molecule with Angstrom Precision.
    T. Furubayashi, K. Motohashi, K. Wakao, T. Matsuda, I. Kii, T. Hosoya, N. Hayashi, M. Sadaie, F. Ishikawa, M. Matsushita, and *S. Fujiyoshi,
    J. Am. Chem. Soc., 139, 8990–8994 (2017). 
    [東工大 プレスリリース]
  67. Facile Transformation of α,β-Unsaturated Carboxylic Acids to Alkenylboronic Esters via Rhodium-Catalyzed Decarbonylative Borylation of α,β-Unsaturated Thioesters.
    *T. Niwa, H. Ochiai, M. Isoda, and *T. Hosoya,
    Chem. Lett., 46, 1315–1318 (2017).
    [Open Access]
    Selected as Editor’s Choice.
  68. Copper-Catalyzed ipso-Borylation of Fluoroarenes.
    *T. Niwa, H. Ochiai, and *T. Hosoya,
    ACS Catal., 7, 4535–4541 (2017).
    Most read article in ACS Catal. Jun.–Jul. 2017
  69. Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular
    dystrophy.
    Y. Sako, K. Ninomiya, Y. Okuno, M. Toyomoto, A. Nishida, Y. Koike, K. Ohe, I. Kii, S. Yoshida, N. Hashimoto, T. Hosoya, M. Matsuo, and *M. Hagiwara,
    Sci. Rep., 7, 46126; doi: 10.1038/srep46126 (2017).
    [Open Access]

  70. Sequential Molecular Conjugation using Thiophene S,S-Dioxides Bearing a Clickable Functional Group.
    T. Meguro, *S. Yoshida, and *T. Hosoya,
    Chem. Lett., 46, 1137–1140 (2017).
    [Open Access]
    Selected as Editor’s Choice.
  71. Facile Synthesis of Phthalides from Methyl ortho-Iodobenzoates and Ketones via an Iodine–Magnesium Exchange Reaction Using a Silylmethyl Grignard Reagent
    Y. Nakamura, *S. Yoshida, and *T. Hosoya,
    Chem. Lett., 46, 858–861 (2017).
    [Open Access]
  72. Enhancing the Synthetic Utility of 3-Haloaryne Intermediates by their Efficient Generation from Readily
    Synthesizable ortho-Iodoaryl Triflate-type Precursors.
    *S. Yoshida, A. Nagai, K. Uchida, and *T. Hosoya,
    Chem. Lett., 46, 733–736 (2017).
    [Open Access]
  73. Three-Component Coupling of Triflyloxy-Substituted Benzocyclobutenones, Organolithium Reagents, and Arynophiles Promoted by Generation of Aryne via Carbon–Carbon Bond Cleavage.
    K. Uchida, *S. Yoshida, and *T. Hosoya,
    Org. Lett., 19 (5), 1184–1187 (2017).
    [TMDU プレスリリース]
  74. Aromatic Azido-selective Reduction via the Staudinger Reaction Using Tri-n-butylphosphonium Tetrafluoroborate with Triethylamine.
    T. Meguro, *S. Yoshida, and *T. Hosoya,
    Chem. Lett., 46 (4), 473–476 (2017).
    [Open Access]
  75. Rhodium-Catalyzed Decarbonylative Borylation of Aromatic Thioesters for Facile Diversification of Aromatic Carboxylic Acids
    H. Ochiai, Y. Uetake, *T. Niwa, and *T. Hosoya,
    Angew. Chem., Int. Ed., 56 (9), 2482–2486 (2017).
    [Open Access]
  76. Facile Synthesis of Multisubstituted Benzo[b]furans via 2,3-Disubstituted 6,7-Furanobenzynes Generated from ortho-Iodoaryl Triflate-type Precursors
    T. Morita, Y. Nishiyama, *S. Yoshida, and *T. Hosoya,
    Chem. Lett., 46, 118–121 (2017).
    [Open Access]
    Selected as Editor’s Choice.
  77. Facile Diversification of Simple Benzo[b]thiophenes via Thienobenzyne Intermediates
    T. Morita, *S. Yoshida, M. Kondo, T. Matsushita, and *T. Hosoya,
    Chem. Lett, 46, 81–84 (2017).
    [Open Access]
  78. Reactions of Arynes with Sulfoximines: Formal Sulfinylamination vs N-Arylation.
    *S. Yoshida, H. Nakajima, K. Uchida, T. Yano, M. Kondo, T. Matsushita, and *T. Hosoya
    Chem. Lett., 46, 77–80 (2017).
    [Open Access]
  79. Aryne Relay Chemistry en Route to Aminoarenes: Synthesis of 3-Aminoaryne Precursors via Regioselective Silylamination of 3-(Triflyloxy)arynes.
    *S. Yoshida, Y. Nakamura, K. Uchida, Y. Hazama, and *T. Hosoya
    Org. Lett, 18, 6212–6215 (2016).
  80. Stereoinversion of Stereocongested Carbocyclic Alcohols via Triflylation and Subsequent Treatment with Aqueous N,N-Dimethylformamide.
    H. Ochiai, T. Niwa, and *T. Hosoya
    Org. Lett., 18, 5982–5985 (2016).
  81. The mevalonate pathway regulates primitive streak formation via protein farnesylation.
    T. Okamoto-Uchida, R. Yu, N. Miyamura, N. Arima, M. Ishigami-Yuasa, H. Kagechika, S. Yoshida, T. Hosoya, M. Nawa, T. Kasama, Y. Asaoka, R. W. Alois, U. Elling, J. M. Penninger, S. Nishina, N. Azuma, and *H. Nishina,
    Sci. Rep., 6, 37697; DOI:10.1038/srep37697 (2016).
    [Open Access]
    東京医科歯科大学プレスリリース
  82. Preparation of Aryne–Nickel Complexes from ortho-Borylaryl Triflates.
    Y. Sumida, T. Sumida, D. Hashizume, and *T. Hosoya
    Org. Lett., 18, 5600–5603 (2016).
    Most read article of Org. Lett. in Nov. 2016.
  83. Blood-brain barrier permeability of ginkgolide: Comparison of the behavior of PET probes 7-[18F]Fluoro- and
    10-O-p-[11C]methylbenzyl ginkgolide B in monkey and rat brains.
    H. Doi, K. Sato, H. Shindou, K. Sumi, H. Koyama, T. Hosoya, Y. Watanabe, S. Ishii, *H. Tsukada, K. Nakanishi, and *M. Suzuki
    Bioorg. Med. Chem., 24, 5148–5157 (2016).
  84. Thiazolobenzyne: a versatile intermediate for multisubstituted benzothiazoles.
    S. Yoshida, T. Yano, Y. Nishiyama, Y. Misawa, M. Kondo, T. Matsushita, K. Igawa, K. Tomooka, and *T. Hosoya
    Chem. Commun., 52, 11199–11202 (2016).
    Selected as inside back cover.
    　
  85. Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation.
    T. Tanaka, K. Okuyama-Dobashi, S. Murakami, W. Chen, T. Okamoto, K. Ueda, T. Hosoya, Y. Matsuura, A. Ryo, Y. Tanaka, M. Hagiwara, and *K. Moriishi
    Antivir. Res., 133, 156–164 (2016).
  86. Controlled Generation of 3-Triflyloxyarynes.
    K. Uchida, *S. Yoshida, and *T. Hosoya
    Synthesis, 48, 4099–4109 (2016).
  87. Single C-F Bond Cleavage of Trifluoromethylarenes with an ortho-Silyl Group.
    *S. Yoshida, K. Shimomori, Y. Kim, and *T. Hosoya
    Angew. Chem., Int. Ed., 55, 10406–10409 (2016).
    Selected as Hot Paper and inside cover.
    東京医科歯科大学プレスリリース
    　
  88. Rhodium-Catalyzed ipso-Borylation of Alkylthioarenes via C–S Bond Cleavage.
    Y. Uetake, T. Niwa, and *T. Hosoya
    Org. Lett., 18, 2758–2761 (2016).
  89. Synthesis of Diverse Benzotriazoles from Aryne Precursors Bearing an Azido Group via Inter- and Intramolecular Cycloadditions.
    S. Yoshida, T. Morita, and *T. Hosoya
    Chem. Lett. 45, 726–728 (2016).
    Selected as Editor’s Choice.
    [Open Access]
  90. Selective inhibition of the kinase DYRK1A by targeting its folding process.
    *I. Kii, Y. Sumida, T. Goto, R. Sonamoto, Y. Okuno, S. Yoshida, T. Kato-Sumida, Y. Koike, M. Abe, Y. Nonaka, T. Ikura, N. Ito,
    H. Shibuya, T. Hosoya, and *M. Hagiwara
    Nat. Commun. 7, 11391: doi:10.1038/ncomms11391 (2016).
  91. Cryfstal structure of nanoKAZ: the mutated 19 kDa component of Oplophorus luciferase catalyzing the bioluminescent reaction with coelenterazine.
    Y. Tomabechi, T. Hosoya, H. Ehara, S. Sekine, M. Shirouzu, and *S. Inouye
    Biochem. Biophys. Res. Commun., 470 (1), 88–93 (2016).

2006-2015

  1. Direct Thioamination of Arynes via Reaction with Sulfilimines and Migratory N-Arylation.
    S. Yoshida, T. Yano, Y. Misawa, Y. Sugimura, K. Igawa, S. Shimizu, K. Tomooka, and *T. Hosoya
    J. Am. Chem. Soc., 137, 14071–14074 (2015).
    Most read article of JACS in Dec. 2015.
    　
  2. Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C–F Bond Functionalizations.
    *T. Niwa, H. Ochiai, Y. Watanabe, and *T. Hosoya
    J. Am. Chem. Soc., 137, 14313–14318 (2015).
    Most read article of JACS in Nov.–Dec. 2015.
    　
  3. A mild and facile synthesis of aryl and alkenyl sulfides via copper-catalyzed deborylthiolation of organoborons with thiosulfonates.
    *S. Yoshida, Y. Sugimura, Y. Hazama, Y. Nishiyama, T. Yano, S. Shimizu, and *T. Hosoya
    Chem. Commun., 51, 16613–16616 (2015).  Selected as inside back cover.
    Highlighted in Chemistry View (Wiley). (News: “Sulfide Synthesis without the Smell”)
    　
  4. Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039.
    M. Okamoto, A. Hidaka, M. Toyama, T. Hosoya, M. Yamamoto, M. Hagiwara, and *M. Baba,
    Antivir. Res., 123, 1–4 (2015).
  5. Concise Synthesis of v-Coelenterazines.
    *T. Hosoya, R. Iimori, S. Yoshida, Y. Sumida, Y. Sahara-Miura, J.-i. Sato, and S. Inouye,
    Org. Lett. 17, 3888–3891 (2015).
  6. Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ.
    R. Sonamoto, *I. Kii, Y. Koike, Y. Sumida, T. Kato-Sumida, Y. Okuno, T. Hosoya, and *M. Hagiwarae,
    Sci. Rep., 5, 12728; doi: 10.1038/srep12728 (2015).
  7. Facile Synthesis of Diverse Multisubstituted ortho-Silylaryl Triflates via C–H Borylation.
    S. Yoshida, K. Shimomori, T. Nonaka, and *T. Hosoya,
    Chem. Lett. 44, 1324–1326 (2015).
  8. Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis.
    S. Masaki, I. Kii, Y. Sumida, T. Kato-Sumida, Y. Ogawa, N. Ito, M. Nakamura, R. Sonamoto, N. Kataoka, T. Hosoya, and *M. Hagiwara,
    Bioorg. Med. Chem., 23 (15), 4434–4441 (2015).
  9. An Alternative Method for Generating Arynes from ortho-Silylaryl Triflates: Activation by Cesium Carbonate in the Presence of a Crown Ether.
    S. Yoshida, Y. Hazama, Y. Sumida, T. Yano, and *T. Hosoya,
    Molecules, 20 (6), 10131–10140 (2015).  Open access
    Special Issue: Development and Application of Aryne Chemistry in Organic Synthesis
  10. Identification of a Dual Inhibitor of SRPK1 and CK2 that Attenuates Pathological Angiogenesis of Macular Degeneration in Mice.
    S. Morooka, M. Hoshina, I. Kii, T. Okabe, H. Kojima, N. Inoue, Y. Okuno, M. Denawa, S. Yoshida, J. Fukuhara, K. Ninomiya, T. Ikura, T. Furuya, T. Nagano, K. Noda, S. Ishida, T. Hosoya, N. Ito, N. Yoshimura, and *M. Hagiwara,
    Mol. Pharmacol., 88, 316–325 (2015)
  11. Generation of cycloheptynes and cyclooctynes via a sulfoxide–magnesium exchange reaction of readily synthesized 2-sulfinylcycloalkenyl triflates.
    S. Yoshida, F. Karaki, K. Uchida, and *T. Hosoya,
    Chem. Commun., 51 (42), 8745–8748 (2015).  Selected as inside front cover
    　
  12. Generation of Arynes Using Trimethylsilylmethyl Grignard Reagent for Activation of ortho-Iodoaryl or ortho-Sulfinylaryl Triflates.
    S. Yoshida, K. Uchida, and *T. Hosoya,
    Chem. Lett., 44 (5), 691–693 (2015). 
    Open access
  13. Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia.
    M. Yoshida, *N. Kataoka, K. Miyauchi, K. Ohe, K. Iida, S. Yoshida, T. Nojima, Y. Okuno, H. Onogi, T. Usui, A. Takeuchi, T. Hosoya, T. Suzuki, and *M. Hagiwara,
    Proc. Natl. Acad. Sci. USA, 112 (9), 2764–2769 (2015).
    京都大学プレスリリース
  14. Boron-Selective Biaryl Coupling Approach to Versatile Dibenzoxaborins and Application to Concise Synthesis of Defucogilvocarcin M.
    Y. Sumida, R. Harada, T. Kato–Sumida, K. Johmoto, H. Uekusa, and T. Hosoya,
    Org. Lett., 16 (23), 6240–6243 (2014).
  15. Substituted 5,6,11,12-Tetradehydrodibenzo[a,e]cyclooctenes: Syntheses, Properties, and DFT Studies of Substituted Sondheimer–Wong Diynes.
    Feng Xu, Lifen Peng, Kenta Shinohara, Takamoto Morita, Suguru Yoshida, Takamitsu Hosoya, Akihiro Orita, and Junzo Otera 
    J. Org. Chem. 79 (23), 11592–11608 (2014).
  16. An efficient generation method and remarkable reactivities of 3-triflyloxybenzyne.
    S. Yoshida, K. Uchida, K. Igawa, K. Tomooka, and T. Hosoya,
    Chem. Commun., 50, 15059–15062 (2014).
  17. Transient Protection of Strained Alkynes from Click Reaction via Complexation with Copper.
    S. Yoshida, Y. Hatakeyama, K. Johmoto, H. Uekusa, and T. Hosoya,
    J. Am. Chem. Soc., 136, 13590–13593. (2014).
  18. Modular synthesis of bis- and tris-1,2,3-triazoles by permutable sequential azide–aryne and azide–alkyne cycloadditions.
    S. Yoshida, T. Nonaka, T. Morita, and T. Hosoya,
    Org. Biomol. Chem., 12, 7489–7493. (2014).
  19. Unconventional secretion of the mutated 19 kDa protein of Oplophorus luciferase (nanoKAZ) in mammalian cells.
    S. Inouye, J.-i. Sato, Y. Sahara–Miura, T. Hosoya, and T. Suzuki,
    Biochem. Biophys. Res. Commun., 450, 1313–1319 (2014).
  20. CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses.
    M. Yamamoto, H. Onogi, I. Kii, S. Yoshida, K. Iida, H. Sakai, M. Abe, T. Tsubota, N. Ito, T. Hosoya, and M. Hagiwara,
    J. Clin. Invest., 124 (8), 3479–3488 (2014).
    京都大学プレスリリース
    朝日新聞（7月9日夕刊 10面）、京都新聞（7月9日夕刊 10面）、産経新聞（7月9日夕刊 8面）、日刊工業新聞（7月11日 17面）、日本経済新聞（7月10日 14面）、読売新聞（7月21日 16面）および科学新聞（8月8日 2面）に掲載され、月刊「化学」Vol. 69, No. 9, P. 73 (2014) や 各種ブログなどでも話題になりました。
  21. Formal C–H-Azidation-Based Shortcut to Diazido Building Blocks for the Versatile Preparation of Photoaffinity Labeling Probes.
    S. Yoshida, Y. Misawa, and T. Hosoya
    Eur. J. Org. Chem., 3991–3995 (2014).
  22. Luminescence enhancement of the catalytic 19 kDa protein (KAZ) of Oplophorus luciferase by three amino acid substitutions.
    *S. Inouye, J. Sato, Y. Sahara–Miura, S. Yoshida, and *T. Hosoya
    Biochem. Biophys. Res. Commun., 445 (1), 157–162 (2014).
  23. [11C]Cetrozole: an Improved C-[11C]Methylated PET Probe for Aromatase Imaging in the Brain.
    K. Takahashi, *T. Hosoya, K. Onoe, H. Doi, H. Nagata, T. Hiramatsu, X.-L. Li, Yu. Watanabe, Y. Wada, T. Takashima, M. Suzuki, H. Onoe, and Y. Watanabe,
    J. Nucl. Med., 55 (5), 852–857 (2014).
  24. IOP-lowering effect of isoquinoline-5-sulfonamide compounds in ocular normotensive monkeys.
    K. Sumi, Y. Inoue, M. Nishio, Y. Naito, T. Hosoya, M. Suzuki, and H. Hidaka,
    Bioorg. Med. Chem. Lett., 24 (3), 831–834 (2014).
  25. Generation of Arynes Triggered by the Sulfoxide–Metal Exchange Reaction of ortho-Sulfinylaryl Triflates.
    S. Yoshida, K. Uchida, and T. Hosoya,
    Chem. Lett., 43, 116 (2014).
  26. Development of bis-unsaturated ester aldehydes as amino-glue probes: Sequential double azaelectrocyclization as promising strategy for bioconjugation.
    K. Tanaka, Y. Nakamoto, E. R. O. Siwu, A. R. Pradipta, K. Morimoto, T. Fujiwara, S. Yoshida, T. Hosoya, Y. Tamura, G. Hirai, M. Sodeoka, and K. Fukase,
    Org. Biomol. Chem., 11 (42), 7326–7333 (2013).
  27. C6-Deoxy coelenterazine analogues as an efficient substrate for glow luminescence reaction of nanoKAZ: the mutated catalytic 19 kDa component of Oplophorus luciferase.
    S. Inouye, J.-i. Sato, Y. Sahara–Miura, S. Yoshida, H. Kurakata, and T. Hosoya,
    Biochem. Biophys. Res. Commun., 437 (1), 23–28 (2013).
  28. Generation of Arynes via Ate Complexes of Arylboronic Esters with an ortho-Leaving Group.
    Y. Sumida, T. Kato, and T. Hosoya
    Org. Lett., 15 (11), 2806–2809 (2013).
  29. Investigation of the effect of active efflux at the blood–brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system.
    M. Miyajima, H. Kusuhara, K. Takahashi, T. Takashima, T. Hosoya, Y. Watanabe, and Y. Sugiyama,
    J. Pharm. Sci., 102 (9), 3309–3319 (2013).
  30. Pd0-mediated rapid coupling of methyl iodide with excess amounts of benzyl- and cinnamylboronic acid esters: efficient method for incorporation of positron-emitting 11C radionuclide into organic frameworks by coupling between two sp3-hybridized carbons.
    H. Koyama, Z. Zhang, R. Ijuin, Siqin, J. Son, Y. Hatta, M. Ohta, M. Wakao, T. Hosoya, H. Doi, and M. Suzuki,
    RSC Adv., 3 (24), 9391–9401 (2013).
  31. Synthesis of diverse aromatic oxophosphorus compounds by the Michaelis–Arbuzov-type reaction of arynes.
    S. Yoshida and T. Hosoya,
    Chem. Lett., 42 (6), 583–585 (2013).
  32. Expression, purification and luminescence properties of coelenterazine-utilizing luciferases from Renilla, Oplophorus and Gaussia: Comparison of substrate specificity for C2-modified coelenterazines.
    S.Inouye, Y. Sahara–Miura, J.-i. Sato, R. Iimori, S. Yoshida, and T. Hosoya
    Protein Expres. Purif., 88 (1), 150–156 (2013).
  33. Site-Specific Attachment of a Protein to a Carbon Nanotube End without Loss of Protein Function.
    S.H. Yoshimura, S. Khan, S. Ohno, T. Yokogawa, K. Nishikawa, T. Hosoya, H. Maruyama, Y. Nakayama, and K. Takeyasu
    Bioconjugate Chem., 23 (7), 1488–1493 (2012).
  34. Palladium-Catalyzed Regio- and Stereoselective Hydrosilylation of Electron-Deficient Alkynes.
    Y.Sumida, T. Kato, S. Yoshida, and T. Hosoya
    Org. Lett., 14 (6), 1552–1555 (2012).
  35. Remodeling of Actin Cytoskeleton in Mouse Periosteal Cells under Mechanical Loading Induces Periosteal Cell Proliferation during Bone Formation.
    D. Sakai, I. Kii, K. Nakagawa, H. N. Matsumoto, M. Takahashi, S. Yoshida, T. Hosoya, K. Takakuda, and A. Kudo
    PLoS ONE, 6: e24847 (2011).
  36. Enhanced clickability of doubly sterically-hindered aryl azides.
    S. Yoshida, A. Shiraishi, K. Kanno, T. Matsushita, K. Johmoto, H. Uekusa, and T. Hosoya
    Sci. Rep., 1, 82; DOI:10.1038/srep00082 (2011).
  37. Positron Emission Tomography Imaging of Aromatase in Gastric Parietal Cells using [11C]Vorozole.
    M. Ozawa, K. Takahashi, K.-h. Akazawa, T. Takashima, H. Nagata, H. Doi, T. Hosoya, Y. Wada, Y. Cui, Y. Kataoka, and Y. Watanabe
    J. Nucl. Med., 52 (12), 1964–1969 (2011).
  38. The Kinase Inhibitor SFV785 Dislocates Dengue Virus Envelope Protein from the Replication Complex and Blocks Virus Assembly.
    A. Anwar, T. Hosoya, K. M. Leong, H. Onogi, Y. Okuno, T. Hiramatsu, H. Koyama, M. Suzuki, M. Hagiwara, and M. A. Garcia-Blanco
    PLoS ONE, 6 (8): e23246.
  39. Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids: PET study with [11C]vorozole.
    K. Takahashi, K. Onoe, H. Doi, H. Nagata, G. Yamagishi, T. Hosoya, Y. Tamura, Y. Wada, H. Yamanaka, C. Yokoyama, H. Mizuma, T. Takashima, M. Bergström, H. Onoe, B. Långström, and Y. Watanabe
    NeuroReport, 22 (7), 326–330 (2011).
  40. Practical synthesis of precursor of [N-methyl-11C]vorozole, an efficient PET tracer targeting aromatase in the brain.
    K. Takahashi, G. Yamagishi, T. Hiramatsu, A. Hosoya, K. Onoe, H. Doi, H. Nagata, Y. Wada, H. Onoe, Y. Watanabe, and T. Hosoya
    Bioorg. Med. Chem., 19 (4), 1464–1470 (2011).
  41. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.
    Y. Ogawa, Y. Nonaka, T. Goto, E. Ohnishi, T. Hiramatsu, I. Kii, M. Yoshida, T. Ikura, H. Onogi, H. Shibuya, T. Hosoya, N. Ito, M. Hagiwara
    Nat. Commun., 1, 86 (2010).
    Nature Japan において 注目の論文 としてとりあげられました。
  42. Application of New Semi-Synthetic Aequorins with Long Half-Decay Time of Luminescence to G-Protein-Coupled Receptor Assay.
    S. Inouye, R. Iimori, Y. Sahara, S. Hisada, and T. Hosoya
    Anal. Biochem., 407 (2), 247–252 (2010).
  43. A single starfish Aurora kinase performs the combined functions of Aurora-A and Aurora-B in human cells.
    Y. Abe, E. Okumura, T. Hosoya, T. Hirota, and T. Kishimoto
    J. Cell Sci., 137 (23), 3978–3988 (2010).
  44. Strain-promoted double-click reaction for chemical modification of azido-biomolecules.
    I. Kii, A. Shiraishi, T. Hiramatsu, T. Matsushita, H. Uekusa, S. Yoshida, M. Yamamoto, A. Kudo, M. Hagiwara, and T. Hosoya
    Org. Biomol. Chem., 8 (18), 4051–4055 (2010).  (selected as inside front cover)
    　
  45. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin β, a substrate of parkin, and reduces its polyubiquitination.
    R. Kohta, Y. Kotake, T. Hosoya, T. Hiramatsu, Y. Otsubo, H. Koyama, Y. Hirokane, Y. Yokoyama, H. Ikeshoji, K. Oofusa, M. Suzuki, and S. Ohta
    J. Neurochem., 114 (5), 1291–1301 (2010).  (selected as  front cover)
  46. Antioxidant, free radical scavenging and NF-κB inhibitory activities of phytosteryl ferulates: Structure-activity studies.
    Md. S. Islam, H. Yoshida, N. Matsuki, K. Ono, R. Nagasaka, H. Ushio, Y. Guo, T. Hiramatsu, T. Hosoya, T. Murata, M. Hori, and H. Ozaki
    J. Pharmacol. Sci., 111 (4), 328–337 (2009).
  47. Functional role of NSP-like 1 protein in membrane translocation of glucose transporter 4.
    T. Ikemoto, T. Hosoya, K. Takata, H. Aoyama, T. Hiramatsu, H. Onoe, M. Suzuki, and M. Endo
    Diabetes, 58 (12), 2802–2812 (2009)
  48. Pd0-Mediated Rapid Coupling between Methyl Iodide and Heteroarylstannanes: An Efficient and General Method for the Incorporation of a Positron-Emitting 11C Radionuclide into Heteroaromatic Frameworks
    M. Suzuki, K. Sumi, H. Koyama, Siqin, T. Hosoya, M. Takashima-Hirano, and H. Do
    Chem. Eur. J., 15 (45), 12489–12495 (2009).
  49. Reconstitution of blue fluorescent protein from recombinant apoaequorin and synthetic coelenteramide.
    S. Inouye and T. Hosoya,
    Biochem. Biophys. Res. Commun., 386 (4), 617-622 (2009)
  50. Palladium(0)-Mediated Rapid Methylation and Fluoromethylation on Carbon Frameworks by Reacting Methyl and Fluoromethyl Iodide with Aryl and Alkenyl Boronic Acid Esters: Useful for the Synthesis of [11C]CH3−C and [18F]FCH2−C-Containing PET Tracers (PET = Positron Emission Tomography).
    H. Doi, I. Ban, A. Nonoyama, K. Sumi, C. Kuang, T. Hosoya, H. Tsukada, and M. Suzuki,
    Chem. Eur. J., 15 (16), 4165-4171 (2009)
  51. Facile synthesis of diazido-functionalized biaryl compounds as radioisotope-free photoaffinity probes by Suzuki−Miyaura coupling.
    T. Hosoya, A. Inoue, T. Hiramatsu, H. Aoyama, T. Ikemoto, and M. Suzuki,
    Bioorg. Med. Chem., 17 (6), 2490-2496 (2009)
  52. Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus
    C. Kuramori, M. Azuma, K. Kume, Y. Kaneko, A. Inoue, Y. Yamaguchi, Y. Kabe, T. Hosoya, M. Kizaki, M. Suematsu, and H. Handa
    Biochem. Biophys. Res. Commun., 379 (2), 519-525 (2009)
  53. Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A
    J. Yomoda, M. Muraki, N. Kataoka, T. Hosoya, M. Suzuki, M. Hagiwara, and H. Kimura
    Genes Cells, 13 (3), 233-244 (2008)
  54. Azidodifluoromethyl-3H-diazirin-3-yl group as an all-in-one functional group for radioisotope-free photoaffinity labeling
    T. Hiramatsu, Y. Guo, and T. Hosoya
    Org. Biomol. Chem., 5 (18), 2916-2919 (2007).
  55. Detection of structural changes in a cofactor binding protein by using a wheat germ cell-free protein synthesis system coupled with unnatural amino acid probing
    M. Abe, S. Ohno, T. Yokogawa, T. Nakanishi, F. Arisaka, T. Hosoya, T. Hiramatsu, M. Suzuki, T. Ogasawara, T. Sawasaki, K. Nishikawa, M. Kitamura, H. Hori, and Y. Endo
    Proteins, 67 (3), 643-652 (2007)
  56. Site-selective Post-translational Modification of Proteins Using an Unnatural Amino Acid, 3-Azidotyrosine
    S. Ohno, M. Matsui, T. Yokogawa, M. Nakamura, T. Hosoya, T. Hiramatsu, M. Suzuki, N. Hayashi, and K. Nishikawa
    J. Biochem., 141 (3), 335-343 (2007).
  57. Neuroprotection by a Central Nervous System-Type Prostacyclin Receptor Ligand Demonstrated in Monkeys Subjected to Middle Cerebral Artery Occlusion and Reperfusion: A Positron Emission Tomography Study
    Y. Cui, H. Takamatsu, T. Kakiuchi, H. Ohba, Y. Kataoka, C. Yokoyama, H. Onoe, Yu. Watanabe, T. Hosoya, M. Suzuki, R. Noyori, H. Tsukada, and Y. Watanabe,
    Stroke, 37 (11), 2830-2836 (2006)
  58. Utilization of host SR protein kinases and RNA splicing machinery during viral replication.
    T. Fukuhara, T. Hosoya, S. Shimizu, K. Sumi, T. Oshiro, Y. Yoshinaka, M. Suzuki, N. Yamamoto, L. A. Herzenberg, L. A. Herzenberg, and M. Hagiwara,
    Proc. Natl. Acad. Sci. USA, 103 (30), 11329-11333 (2006)
  59. Rapid methylation on carbon frameworks useful for the synthesis of 11CH3-incorporated PET tracers: Pd(0)-mediated rapid coupling of methyl iodide with an alkenyltributylstannane leading to a 1-methylalkene.
    T. Hosoya, K. Sumi, H. Doi, M. Wakao, and M. Suzuki,
    Org. Biomol. Chem., 4 (3), 410-415 (2006).

Before 2005

  1. Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle.
    T. Hosoya, T. Hiramatsu, T. Ikemoto, H. Aoyama, T. Ohmae, M. Endo, and M. Suzuki,
    Bioorg. Med. Chem. Lett., 15 (5), 1289-1294 (2005).
  2. Manipulation of alternative splicing by a newly developed inhibitor of Clks.
    M. Muraki, B. Ohkawara, T. Hosoya, H. Onogi, J. Koizumi, T. Koizumi, K. Sumi, J. Yomoda, M. V. Murray, H. Kimura, K. Furuichi, H. Shibuya, A. R. Krainer, M. Suzuki, and M. Hagiwara,
    J. Biol. Chem., 279 (23), 24246-24254 (2004).
  3. Novel bifunctional probe for radioisotope-free photoaffinity labeling: compact structure comprised of photospecific ligand ligation and detectable tag anchoring units.
    T. Hosoya, T. Hiramatsu, T. Ikemoto, M. Nakanishi, H. Aoyama, A. Hosoya, T. Iwata, K. Maruyama, M. Endo, and M. Suzuki,
    Org. Biomol. Chem., 2 (5), 637-641 (2004).
  4. Rapid methylation of terminal acetylenes by the Stille coupling of methyl iodide with alkynyltributylstannanes: a
    general protocol potentially useful for the synthesis of short-lived 11CH3-labeled PET tracers with a 1-propynyl group.
    T. Hosoya, M. Wakao, Y. Kondo, H. Doi, and M. Suzuki,
    Org. Biomol. Chem., 2 (1), 24-27 (2004).
  5. Dantrolene Analogues Revisited: General Synthesis and Specific Functions Capable of Discriminating Two Kinds of
    Ca2+ Release from Sarcoplasmic Reticulum of Mouse Skeletal Muscle.
    T. Hosoya, H. Aoyama, T. Ikemoto, Y. Kihara, T. Hiramatsu, M. Endo, and M. Suzuki,
    Bioorg. Med. Chem., 11 (5), 663-673 (2003).
  6. [125I]-N-[(3-Azido-5-iodo)benzyl]dantrolene and [125I]-N-{[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl}
    dantrolene: Photoaffinity Probes Specific for the Physiological Ca2+ Release from Sarcoplasmic Reticulum of Skeletal
    Muscle.
    T. Hosoya, H. Aoyama, T. Ikemoto, T. Hiramatsu, Y. Kihara, M. Endo, and M. Suzuki,
    Bioorg. Med. Chem. Lett., 12 (22), 3263-3265 (2002).
  7. Facile access to versatile polyaromatic building blocks: selectively protected benzocyclobutenedione derivatives via
    regioselective [2 + 2] cycloaddition of a-alkoxybenzyne and ketene silyl acetal.
    T. Hamura, T. Hosoya, H. Yamaguchi, Y. Kuriyama, M. Tanabe, M. Miyamoto, Y. Yasui, T. Matsumoto, and K. Suzuki,
    Helv. Chim. Acta, 85 (11), 3589-3604 (2002).
  8. Inhibition of Rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in
    human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.
    M. Ikenoya, H. Hidaka, T. Hosoya, M. Suzuki, N. Yamamoto, and Y. Sasaki,
    J. Neurochem., 81 (1), 9-16 (2002).
  9. Specific ligand for a central type prostacyclin receptor attenuates neuronal damage in a rat model of focal cerebral
    ischemia.
    H. Takamatsu, H. Tsukada, Yu. Watanabe, Y.-L. Cui, Y. Kataoka, T. Hosoya, M. Suzuki, and Y. Watanabe,
    Brain Res., 925 (2), 176-182 (2002).
  10. Effects of dantrolene and its derivatives on the Ca2+ release in the sarcoplasmic reticulum of mouse skeletal muscle fibres.
    T. Ikemoto, T. Hosoya, H. Aoyama, Y. Kihara, M. Suzuki, and M. Endo,
    Br. J. Pharmacol., 134 (4), 729-736 (2001).
  11. Silicon-Directed Regioselective [2+2] Cycloaddition of alpha-Alkoxybenzyne and Ketene Silyl Acetals.
    T. Hosoya, T. Hamura, Y. Kuriyama, M. Miyamoto, T. Matsumoto, and K. Suzuki,
    Synlett, (4), 520-522 (2000).
  12. Total synthesis of ravidomycin: revision of absolute and relative stereochemistry.
    S. Futagami, Y. Ohashi, K. Imura, T. Hosoya, K. Omori, T. Matsumoto, and K. Suzuki,
    Tetrahedron Lett., 41 (7), 1063-1067 (2000).
  13. [35S]S-[5-(4-benzoylphenyl)pentyl]glutathione: A Versatile Radioligand Targeting GS-X Pumps with the Ability of Photoaffinity Labeling.
    K. Furuta, T. Hosoya, K. Tomokiyo, S. Okuda, A. Kuniyasu, H. Nakayama, T. Ishikawa, and M. Suzuki,
    Bioorg. Med. Chem. Lett., 9 (18), 2661-2666 (1999).
  14. On the Stereochemistry of Aryl C-Glycosides: Unusual Behavior of Bis-TBDPS Protected Aryl C-Olivosides.
    T. Hosoya, Y. Ohashi, T. Matsumoto, and K. Suzuki,
    Tetrahedron Lett., 37 (5), 663-666 (1996).
  15. Total Syntheses of BE-12406 A and Its C(8)-Vinyl Analog.
    T. Hosoya, E. Takashiro, Y. Yamamoto, T. Matsumoto, and K. Suzuki,
    Heterocycles, 42 (1), 397-414 (1996).
  16. Convenient Synthesis of Phthalides via Regioselective Baeyer−Villiger Oxidation of Benzocyclobutenones.
    T. Hosoya, Y. Kuriyama, and K. Suzuki,
    Synlett, (6), 635−638 (1995).
  17. Stereospecificity in [2 + 2] Cycloaddition of Benzyne and Ketene Silyl Acetal.
    T. Hosoya, T. Hasegawa, Y. Kuriyama, and K. Suzuki,
    Tetrahedron Lett., 36 (19), 3377-3380 (1995).
  18. [2 + 2] Cycloaddition of Benzyne and Ketene Silyl Acetal as an Efficient Route to Benzocyclobutenones.
    T. Hosoya, T. Hasegawa, Y. Kuriyama, T. Matsumoto, and K. Suzuki,
    Synlett, (2), 177-179 (1995).
  19. First Total Synthesis of BE-12406 A.
    T. Hosoya, E. Takashiro, T. Matsumoto, and K. Suzuki,
    Tetrahedron Lett., 35 (26), 4591-4594 (1994).
  20. Total Synthesis of the Gilvocarcins.
    T. Hosoya, E. Takashiro, T. Matsumoto, and K. Suzuki,
    J. Am. Chem. Soc., 116 (3), 1004-1015 (1994).
  21. Total Synthesis and Absolute Stereochemical Assignment of Gilvocarcin M.
    T. Matsumoto, T. Hosoya, and K. Suzuki,
    J. Am. Chem. Soc., 114 (9), 3568-3570 (1992).
  22. New Efficient Protocol for Aryne Generation. Selective Synthesis of Differentially Protected 1,4,5-Naphthalenetriols.
    T. Matsumoto, T. Hosoya, M. Katsuki, and K. Suzuki,
    Tetrahedron Lett., 32 (46), 6735-6736 (1991).
  23. O→C-Glycoside Rearrangement of Resorcinol Derivatives. Versatile Intermediates in the Synthesis of ArylC-Glycosides.
    T. Matsumoto, T. Hosoya, and K. Suzuki,
    Synlett, (10), 709-711 (1991).
  24. Improvement in O→C-Glycoside Rearrangement Approach to C-Aryl Glycosides: Use of 1-O-Acetyl Sugar as but Efficient Glycosyl Donor.
    T. Matsumoto, T. Hosoya, and K. Suzuki,
    Tetrahedron Lett., 31 (32), 4629-4632 (1990).

Reviews/Books

  1. 塩基を添加しないクロスカップリングの開発 ―大型放射光施設を活用した反応機構の解析―
    丹羽　節, 植竹裕太, 細谷孝充, 化学, 77 (5), 12–16 (2022).
  2. 異種アジド選択的反応
    細谷孝充, ファルマシア, 57 (11), 989–993 (2021).
  3. Recent Insertion Reactions of Aryne Intermediates. Chapter 4 in Modern Aryne Chemistry (Ed. A. T. Biju; Wiley-VCH),
    S. Yoshida, T. Hosoya, pp. 111–148 (2021).
  4. Molecular Renovation Strategy for Expeditious Synthesis of Molecular Probes.
    *T. Niwa, *T. Hosoya, Bull. Chem. Soc. Jpn. 93 (2), 230–248 (2020).
  5. Recent Advances in Synthetic Hetaryne Chemistry.
    Y. Nakamura, *S. Yoshida, *T. Hosoya
    Heterocycles, 98 (12), 1623–1677 (2019).
  6. 芳香族フッ化物の脱フッ素ホウ素化反応
    *丹羽　節, *細谷孝充, 有機合成化学協会誌（J. Synth. Org. Chem., Jpn.）, 77 (9), 883–894 (2019).
  7. Target Identification of Bioactive Compounds by Photoaffinity Labeling Using Diazido Probes
    “Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules:
    The Shape of Organic Synthesis to Come”
    S. Yoshida, and T. Hosoya (Ed. by Y. Kobayashi), Springer, pp. 335-355 (2019).
  8. 多成分集積を指向した合成のためのアライン化学
    内田 圭祐, *吉田 優, *細谷孝充
    有機合成化学協会誌, 77, 145–162 (2019).
  9. Recent advances in reactions between arynes and organosulfur compounds
    T. Matsuzawa, *S. Yoshida, and *T. Hosoya
    Tetrahedron Lett. 2018, 59, 4197–4208.
  10. 分子をつくり変える ―PETイメージングへの応用に向けて―
    丹羽　節, 細谷孝充, 現代化学, 568 (7), 42–46 (2018).
  11. 低分子PETプローブの開発
    丹羽　節, 細谷孝充
    日本レーザー医学会誌, in press (2016).
  12. 2種のアジド分子を効率的に連結する手法の開発
    吉田　優, 喜井　勲, 細谷孝充
    有機合成化学協会誌, 74 (5), 453–461 (2016).
  13. The Renaissance and Bright Future of Synthetic Aryne Chemistry.
    S. Yoshida and *T. Hosoya
    Chem. Lett., 44 (11), 1450–1460 (2015).
  14. CDK9を標的とした次世代抗ウイルス薬FIT-039の開発
    山本　誠,小野木博, 細谷孝充, 萩原正敏, ケミカルバイオロジー, 8 (1), 2–5 (2015).
  15. 逐次環化付加反応によるビストリアゾール合成
    吉田　優, 細谷孝充, 化学工業, 66 (5), 389–393 (2015).
  16. 「生物活性分子のケミカルバイオロジー：標的同定と作用機構（CSJカレントレビュー19）」（日本化学会 編）,
    Part II　4章　光親和性標識法の基礎と実際
    細谷孝充, 吉田　優, 化学同人, pp. 63–70 (2015).
  17. 「生物活性分子のケミカルバイオロジー：標的同定と作用機構（CSJカレントレビュー19）」（日本化学会 編）,
    Part I　2章　Basic concept-2：標的分子同定の基礎
    細谷孝充, 吉田　優, 化学同人, pp. 20–25 (2015).
  18. 「クリックケミストリー ―基礎から実用まで―」（高田十志和、小山靖人、深瀬浩一 編）
    第3章　異種アジド基の反応性の差を利用した分子連結
    細谷孝充, 吉田　優, シーエムシー出版, pp. 18–28 (2014).
  19. 「くすり（候補）」の効き方を調べる―新しい光親和性標識法の開発
    細谷孝充, 吉田　優,
    実験医学増刊「研究成果を薬につなげる アカデミア創薬の戦略と実例」（長野哲雄 編）, 32 (2), 212–221 (2014).
  20. Pd0-Mediated Rapid Cross-Coupling Reactions, the Rapid C-[11C]Methylations, Revolutionarily Advancing the
    Syntheses ofShort-Lived PET Molecular Probes.
    M.Suzuki, H. Doi, H. Koyama, Z. Zhang, T. Hosoya, H. Onoe, and Y. Watanabe,
    Chem. Rec., 14 (3), 516–541 (2014).
  21. 「ケミカルバイオロジー 成功事例から学ぶ研究戦略」（H. Waldmann, P. Janning 編; 長野哲雄, 萩原正敏 監訳）
    6章  光親和性標識法による抗生物質リネゾリドの標的分子および結合部位の同定
    吉田優, 細谷孝充, 丸善出版, pp. 89–99; pp. 271–283 (2013).
  22. 「ケミカルバイオロジー 成功事例から学ぶ研究戦略」（H. Waldmann, P. Janning 編; 長野哲雄, 萩原正敏 監訳）
    18章  グアニン四重鎖リガンドを利用したc-MYCの転写調節機構の解明
    隅田有人, 細谷孝充, 丸善出版, pp. 89–99; pp. 271–283 (2013).
  23. ダブルクリック反応による新規生体分子標識法
    細谷孝充, G. I. Research, 21 (5), 372–378 (2013).
  24. 生物発光系によるin vivoイメージングを指向した発光基質の開発
    細谷孝充, 隅田有人,吉田　優, 鈴木崇弘、井上　敏
    JSMI Report （日本分子イメージング学会機関誌）, 6 (1), 3–6 (2013).
  25. 異種アジド選択的反応：かさ高い芳香族アジドの意外な反応性の発見
    菅野貴美幸, 吉田　優, 細谷孝充, ケミカルバイオロジー, 5 (1), 11–15 (2012).
  26. ダブルクリック反応：生体分子の新しい化学修飾法
    喜井　勲, 吉田　優, 細谷孝充, 生化学, 84 (4), 306–311 (2012).
  27. Biological Abilities of Rice Bran-derived Antioxidant Phytochemicals for Medical Therapy.
    Md. S. Islam, R. Nagasaka, K. Ohara, T. Hosoya, H. Ozaki, *H. Ushio, and *M. Hori,
    Curr. Top. Med. Chem., 11, 1847–1853 (2011).
  28. 「医療・診断ををめざす先端バイオテクノロジー（バイオ研究のフロンティア３）」（関根光雄編）
    15章  光親和性標識法
    細谷孝充, 工学図書, pp. 141–150 (2009).
  29. アジド基の特性を利用したnon-RI光親和性標識法の開発
    細谷孝充, 有機合成化学協会誌, 65 (9), 842-851 (2007).
  30. 標的タンパク質探索の化学
    細谷孝充, 化学工業, 58 (5), 345−350 (2007).
  31. 生体可視化用分子プローブの創製と活用
    鈴木正昭, 土居久志, 細谷孝充,
    オプトロニクス, 25 (3), 94−100 (2006).
  32. 脳化学：PET研究基盤を刷新するプローブ創製と11C新導入法
    鈴木正昭, 土居久志, 細谷孝充,
    神経研究の進歩, 49 (6), 939−947 (2005).
  33. Rapid methylation on carbon frameworks leading to the synthesis of a PET tracer capable of imaging a novel
    CNS-typep rostacyclin receptor in living human brain.
    M. Suzuki, H. Doi, T. Hosoya, B. Långström, and Y. Watanabe,
    Trends Anal. Chem., 23 (8), 595-607 (2004).
  34. 「先端の分析法−理工学からナノ・バイオまで−」
    第10章　生体トモグラフィー　第1節　PET
    鈴木正昭, 土居久志, 細谷孝充, 塚田秀夫,
    エヌ・ティ−・エス, pp. 814−829 (2004).
  35. Positron Emission Tomography（PET）法による生体の分子イメージング研究と創薬・医療への応用
    鈴木正昭, 土居久志, 細谷孝充, 渡辺恭良,
    生物物理, 44 (6), 265−270 (2004).
  36. 脳を探る分子プローブ設計：ヒト脳内IP2受容体の分子イメージング
    鈴木正昭, 土居久志, 加藤孝一, 細谷孝充, 渡辺由美子, 渡辺恭良,
    日本神経精神薬理学雑誌 (Jpn. J. Neuropsychopharmacol.), 24 (4), 221−229 (2004).
  37. 生体系の非破壊分析（９）：PET法による脳内中枢型プロスタサイクリン受容体の分子イメージング
    鈴木正昭, 土居久志, 細谷孝充, 渡辺恭良,
    現代化学, 387 (6), 46−54 (2003).
  38. 設計PGプローブによるヒト脳内IP2受容体の分子イメージング
    鈴木正昭, 土居久志, 細谷孝充, Bengt Långström, 渡辺由美子, 渡辺恭良,
    細胞工学, 22 (2), 167−171 (2003).
  39. Palladium-catalyzed rearrangements of oxygen functions.
    In Handbook of Organopalladium Chemistry for Organic Synthesis (Ed. E. Negishi; John Wiley & Sons),
    M. Suzuki, T. Hosoya, and R. Noyori,
    Vol. 2, pp. 2939−2954 (2002).
  40. 「設計分子による生体機能制御ソフトの構築」を目指して
    鈴木正昭, 古田享史, 細谷孝充,
    有機合成化学協会誌, 55 (5), 365−374 (1997).
  41. Total Synthesis of the Gilvocarcins.
    K. Suzuki, T. Matsumoto, and T. Hosoya,
    有機合成化学協会誌, 53 (11), 1045−1054 (1995).
  42. ハイブリッド型抗腫瘍性化合物ギルボカルシン類の全合成
    鈴木啓介, 松本隆司, 細谷孝充,
    化学と工業, 46 (7), 1103−1105 (1993).

Patent

  1. 血管新生増殖因子を阻害する医薬組成物
    萩原正敏, 諸岡　諭, 細谷孝充, 吉田　優, WO 2015/147204.
  2. アリールボロン酸エステル化合物の製造方法
    丹羽　節, 細谷孝充, WO 2015/137175.
  3. 疼痛に関する化合物及び医薬組成物
    萩原正敏, 豊本雅靖, 細谷孝充, 吉田　優, 栗原　崇, WO 2015/093567.
  4. 疾病の発症又は進行の一因となる異常スプライシングを抑制できる物質のスクリーニング方法
    萩原正敏, 吉田　優, 細谷孝充, WO 2015/005491.
  5. 精神神経疾患又は悪性腫瘍に関する化合物及び医薬組成物
    萩原正敏, 小野木博, 喜井　勲, 細谷孝充, 隅田有人, WO 2014/021337, US 2015/225421.
  6. スクリーニング方法、タンパク質の不安定性及び/又は安定性を誘導する物質、及び、タンパク質の活性評価
    萩原正敏, 喜井　勲, 細谷孝充, 隅田有人, 吉田　優, WO 2013/183718.
  7. Antivirus composition （抗ウイルス組成物）
    萩原正敏, 奥野友紀子, 細谷孝充, 小野木博, 吉田　優, WO 2013/137456.
  8. ベンゾチオフェン化合物、該化合物を有効成分とするオルタナティブオートファジー誘導剤及び抗癌剤、
    並びに抗癌活性を有する化合物をスクリーニングするための方法
    清水重臣, 細谷孝充, 室橋道子, 吉田　優, WO 2013/118842, EP 2813226, US 2015/0056141.
  9. v-セレンテラジン化合物の製造方法
    井上　敏, 佐原由依子, 吉田　優, 細谷孝充
    特開2012-188354, US 2012/0232272, GB2488894, US 2014/0206868
    【特許US 8772484, JP特許第5637907号, US 8975403, JP特許第5837973号】.
  10. セレンテラジン類縁体及びセレンテラミド類縁体
    井上　敏, 佐原由依子, 細谷孝充
    特開2011-219392, US 2011/0244481, GB2479441, US 2014/0120538, US 2014/0316137
    【特許US 8642281, JP特許第5605727号, 特許US 8883432, 特許US 9056840, 特許US 9075058】.
  11. 環状化合物、環状化合物の製造方法および生体分子の修飾法
    細谷孝充, 喜井　勲, 吉田　優, 松下武司
    WO 2011/118394
  12. PET用標識化合物
    渡辺恭良, 尾上浩隆, 高橋佳代, 鈴木正昭, 土居久志, 細谷孝充
    WO 2011/002096, US 2012/0230914 【JP特許第5777163号】.
  13. セレンテラジン類縁体及びその製造方法
    井上　敏, 佐原由依子, 飯森理絵, 細谷孝充
    WO 2010/090319, US 2012/0035070, GB 2479847
    【特許US 8546568, GB 2479847, US 8765921, JP特許第5582505号】.
  14. セレンテラミド類縁体
    細谷孝充, 岡　光平, 井上　敏
    WO 2010/090318, US 2011/0288280, GB 2479692
    【特許US 8431525, GB 2479692, JP特許第5534346号】.
  15. DYRKを阻害する化合物を含有する医薬組成物
    萩原正敏, 澁谷浩司, 大西英理子, 小川　靖, 細谷孝充, 平松俊行, 吉田実代
    WO 2010/010797.
  16. 抗RNAウイルス作用を有するアニリン誘導体
    小野木博, 萩原正敏, 鈴木正昭, 古山浩子, 細谷孝充, 平松俊行
    WO 2009/119167, US 2011/0059950.
  17. アリールO－グルコシドの製造方法
    細谷孝充, 山岸　玄, 渡辺恭良
    特開2009-184953.
  18. 抗DNAウイルス作用を有するアニリン誘導体
    小野木博, 萩原正敏, 細谷孝充, 山本　誠, 野中洋介, 平松俊行
    WO 2009/020198.
  19. メチル基を含有する化合物を調製するための高速メチル化法
    鈴木正昭, 細谷孝充
    WO 2007/046258, US 2009/0238759 【特許US 8067631】.
  20. SR蛋白質のリン酸化制御方法、および、SR蛋白質の活性制御剤を有効成分とする抗ウイルス剤
    萩原正敏, 福原武志, 鈴木正昭, 細谷孝充
    WO 2005/063293, AU 2004/308825, US 2007/0135367, US 2010/0016359 【特許US 7569536】.
  21. 非天然蛋白質、その製造方法、固定化方法及びキット
    西川一八, 鈴木正昭, 横川隆志, 細谷孝充, 大野　敏
    特開2004-261160 【JP特許第3896460号】.

東京科学大学 総合研究院 生体材料工学研究所

生命有機化学分野（細谷研究室）

〒101-0062千代田区神田駿河台 2-3-10
東京科学大学 IIR 生体材料工学研究所 110A（教授室）

Chemical Bioscience Team

Laboratory for Biomaterials and Bioengineering (LBB)
Institute of Integrated Research (IIR)
Institute of Science Tokyo

#110A, Laboratory for Biomaterials and Bioengineering,
Institute of Integrated Research, Institute of Science Tokyo
2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan

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